The Serie A champions and Napoli are two of the best teams in the world, but who will take home the points?
It will come down to the final whistle, which will decide who is the better team.
Juventus are one of the most powerful teams in Serie A, but they are the only team to score in six of the last seven games, and the two sides only have a draw.
Napoli, on the other hand, have won seven of their last eight and will be hoping to avoid a first defeat of the season.
They could come away with a victory after winning their opening four matches and holding off Juventus, but that is a tall order for an underdogs, especially after they had to beat Milan to avoid relegation in the summer.
Napoli, meanwhile, have not had the best run of form recently.
They are currently fourth in Serie B, six points behind second-placed Roma and just a point off fourth-placed Genoa.
They have won three of their past four, but a home defeat to AC Milan on Monday night was enough to give their title hopes a boost.
What to watch forInjuries to Andrea Pirlo and David De Gea have led to Napoli’s inability to attack, and they have only scored eight goals in 11 games.
Their only goal has come in the last two games, as they came close to scoring in the final minutes of the first half against AC Milan.
Juventus’ injury problems mean they are unlikely to get to grips with the task of playing against Napoli.
Pirla and De Geha will miss the clash due to a calf injury, while Leonardo Bonucci is also still nursing an ankle problem.
The Italian international has been ruled out for the game with a knee injury, but he could be fit for the trip to Naples.
Napolitano is likely to start Bonucci at right-back and Andrea Padoan at centre-back.
Juve have had the better of the title race since the beginning of the year, but will they make it to the last eight?
They are in the same position as the champions, but their form has improved as the season has progressed.
They won their first four games and finished the campaign in third place, but have struggled to find the net.
Napolitano was in fine form in Serie C in the first two months of the campaign, but his form has fallen off significantly this term.
He was just 13th in the league in terms of goals scored and he has conceded 22 goals this term, compared to 18 in all competitions.
He has been more of a problem for the Italians, as he has scored six goals in eight games, with just one of those coming in the 1-0 win over Udinese.
Juventina’s only goal of the match came in the 2-1 win at the Stadio San Paolo last week, when Mario Mandzukic hit the bar from close range.
He is out of contract at the end of the 2018/19 season, and it will be interesting to see how he fares when he returns.
He also had a brief spell on the sidelines after sustaining an ankle injury in the second leg of the Inter-Milan game last month.
Juvenile midfielder Lucas Digne is another one of Napoli and Juventus’ future stars.
He scored six Serie A goals in the season opener against Genoa, but was not fit to play in the match.
He will miss Napoli for the return leg at the Santiago Bernabeu, but is expected to return to full fitness on Monday.
Napoleon Lescott is the other player Juventus need to keep an eye on.
He had a quiet start to the season before scoring the opener against Udinese in the derby, but scored the equaliser against Milan on Sunday.
He could be a good option for the second half of the game.
Napolÿnoli are the top-ranked team in Serie D, with seven points, but Juventus are two points ahead of them and are three points ahead on goal difference.